Author

Kwan Hyi Lee

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Review Open access Sep 2026

Synthetic lethality and context-selective DNA-damage response dependencies: from genetic vulnerability to pharmacological translation.

Synthetic lethality has established DNA-damage response (DDR) dependencies as a major strategy for precision cancer therapy, exemplified by targeting BRCA1/2 and poly(ADP-ribose) polymerase (PARP). However, genetic dependency alone does not ensure pharmacological tractability or clinical utility. Emerging targets, incl...

Nayoon Jo, Su-Jin Kang, Jeongeun Kim et al. · Drug Discovery Today · 0 citations

Jul 2026

Direct Potentiometric Detection of Multiple Viral Nucleic Acids via Cas12a-Integrated Field-Effect Transistor Biosensors

The rapid diagnosis of high-risk viral pathogens is critical for public health, yet current nucleic acid-based methods often necessitate pre-amplification steps. These processes can introduce amplification bias and hinder accurate quantification. To address these limitations, we report a Cas12a-mediated Field-Effect Tr...

Kwan Hyi Lee, Hyung Joon Park, Seuk-Min Ryu · ECS Meeting Abstracts · 0 citations