Short-Term 6PPD-Q Exposure alters Tight-Junction-Related Gene Expression Without Acute Lethality in Japanese Medaka Oryzias latipes.
6PPD-quinone (6PPD-Q), a transformation product of the tire antioxidant 6PPD, causes acute mortality in several salmonid species, but its toxicity varies markedly among fish species. Disruption of vascular-barrier integrity and inflammatory signaling has been proposed as a key mechanism of 6PPD-Q toxicity. However, it...