Inflammatory-metabolic coupling in glia: LCN2-PDK axis as molecular mechanism and therapeutic paradigm.
Neuroinflammation and metabolic dysfunction converge in diverse neurological disorders, yet the molecular mechanisms linking these processes remain incompletely defined. This review integrates current evidence that the lipocalin-2 (LCN2) - pyruvate dehydrogenase kinase (PDK) axis represents a candidate mechanistic path...