Open access
Oct 2026
TCF21 loss identifies a conserved inflammation-associated fibroblast state across Crohn’s disease and ulcerative colitis
Background and Aims Inflammatory bowel diseases (IBD), including Crohn’s disease (CD) and ulcerative colitis (UC), are associated with stromal remodeling; however, the fibroblast states that contribute to chronic inflammation remain incompletely defined. We aimed to identify conserved pathogenic fibroblast programs acr...
Mor Hindi Malowany, Noah Franklin, Matthew V. Russo et al.
· bioRxiv · 0 citations