Author

L. Berikashvili

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Open access Oct 2026

The Critical Clock: Time-Dependent Inflammation, Catabolism and Immunosuppression Syndrome Is Associated with ICU Mortality

Background/Objectives: Chronic critical illness (CCI) is increasingly recognized as a major challenge in intensive care, yet its definition remains heterogeneous. The triad of inflammation, catabolism, and immunosuppression (ICS) is central to proposed CCI pathophysiology, but the association between its changing compo...

V. Likhvantsev, L. Berikashvili, P. Polyakov et al. · Diagnostics · 0 citations

Open access Oct 2026

Critical Episodes of Inflammation, Catabolism, and Immunosuppression Define Mortality Risk in Chronic Critical Illness

Background/Objectives: A globally recognized definition of chronic critical illness (CCI) is lacking. Temporal criteria produce variable estimates, while pathophysiological models emphasize inflammation, catabolism, and immunosuppression (ICS). The relationship between ICS dynamics and mortality remains unclear. Method...

V. Likhvantsev, L. Berikashvili, P. Polyakov et al. · Journal of Clinical Medicine · 0 citations

Open access Oct 2026

Prospective internal validation of an XGBoost-based machine learning model for sepsis prediction in patients with prolonged ICU stays

Introduction: to prospectively validate a previously developed machine learning model for predicting sepsis onset in this patient population. Methods: Prospective validation was conducted in accordance with TRIPOD+AI recommendations using data from the Russian Intensive Care Dataset (RICD v3.0). The XGBoost-based mode...

M. Yadgarov, O. Rebrova, S. Shvyrev et al. · Medical Doctor and Informati... · 0 citations