Author

L. Bonanno

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Review Open access Jul 2026

Anti-TROP2 Antibody Drug Conjugates in EGFR-Mutant Non-Small Cell Lung Cancer: Biological Rationale and Clinical Challenges

The emergence of antibody-drug conjugates (ADCs) targeting trophoblast cell-surface antigen 2 (TROP2) represents a potential paradigm shift in the treatment of EGFR-mutated non-small cell lung cancer (NSCLC), a setting historically characterized by limited therapeutic options following progression on EGFR tyrosine kina...

L. Bonanno, Alberto Ronchi, Loc Carlo Bao et al. · Pharmaceutics · 0 citations

Open access Jul 2026

Comparing Real-Time PCR and Amplicon-Based NGS for Routine EGFR Liquid Biopsy Profiling

This study evaluated the amplicon-based NGS Plasma-SeqSensei™ Solid Cancer In Vitro Diagnostics (IVD) Kit (Sysmex) against the real-time PCR-based cobas® EGFR Mutation Test v2 (Roche), the current routine standard at the Veneto Institute of Oncology IOV-IRCCS, finding it to be a robust and highly sensitive assay.

Andrea Boscolo Bragadin, Valeria Tosello, S. Longo et al. · Diagnostics · 0 citations