Author

L. Brais

2 papers indexed here

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Sep 2026

Abstract B110: Effector CD4 T cells convert transient responses to KRAS targeted therapy into long-term durable remissions in pancreatic cancer

Pancreatic ductal adenocarcinoma is refractory to most therapies, including immunotherapies, where reinvigoration of CD8 T cells with immune checkpoint blockade is insufficient to induce long-term durable remissions. Direct inhibitors of KRAS are clinically promising, although acquired resistance is common. To test i...

Li Qiang, Megan T. Hoffman, Jung-Ho Chun et al. · Cancer Research · 0 citations

Open access Aug 2026

A compendium of next-generation patient-derived models for diverse cancers

The development of new therapeutics and the validation of pathogenetic cancer mechanisms require representative laboratory models1,2. However, existing collections represent only a fraction of the diversity observed in human cancer2, 3–4. Recent technologies have enabled efficient in vitro model derivation (for example...

Dina Elharouni, Mushriq Al-Jazrawe, Seongmin Choi et al. · Nature · 3 citations