L. Bunse

Immuntherapien bei primären Hirntumoren

T cell immunomonitoring: a comparative analysis of traditional and novel methods to quantify and characterize human antigen-specific T cells.

Tissue resident CD4+ memory T-cells mark response to immune checkpoint inhibition in high-grade glioma

Background Immune checkpoint inhibitors (ICI) are efficacious in many solid tumors, but response in glioma is restricted to a small subgroup. The determinants of response and resistance to ICI remain poorly understood. Methods Here we exploit a syngeneic hypermutated high-grade glioma model with dichotomous response to...

Latent effector T cells mediate immunotherapy responses in the bone marrow microenvironment.

TFiT (tumor-reactive features in T cells), a transcriptional classifier that identifies tumor-reactive T cells and stratifies immunotherapy, but not chemotherapy, response across independent MM and AML cohorts, supporting its specificity for T cell-mediated tumor control.

Perspectives of Biophysical Therapies in Glioblastoma.

Biophysical therapies are best conceived as adjunctive tools within multimodal glioblastoma management rather than stand-alone solutions, with a strong focus on predictive biomarker-driven, mechanistically informed trial designs.