Author

L. Chatel-Chaix

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Open access Sep 2026

Atlastin-2-mediated endoplasmic reticulum membrane tethering is critical for flavivirus replication

Flaviviruses (genus Orthoflavivirus) are arthropod-borne viruses which cause approximately 400 million annual global infections in humans. Flavivirus infection requires cellular machinery to facilitate replication and spread. All known flaviviruses replicate in association with the host endoplasmic reticulum (ER), wher...

Jonathan E. Owen, Cheyanne L. Bemis, Qing-Yin Wang et al. · PLoS Biology · 0 citations

Open access Jul 2026

Single-cell analysis of Powassan virus-infected brains reveals age-dependent neuroinflammatory crosstalk and progressive Alzheimer’s-like APP/Aβ accumulation

ABSTRACT Powassan virus (POWV) causes lethal encephalitis in the elderly and long-term neurological sequelae in survivors. Mirroring human disease, POWV strain LI9 directs age-dependent lethality in C57BL/6 (B6) mice, resulting in spongiform encephalitis, gliosis, and inflammatory cytokine/chemokine responses in the CN...

M. R. D. de Souza, M. Lindner, Megan Mladinich-Valenti et al. · mBio · 1 citation