Review
Open access
2026
Cardiovascular outcomes and safety of chlorthalidone versus hydrochlorothiazide: A systematic review and meta-analysis
Background: For decades, chlorthalidone (CTD) was favoured over hydrochlorothiazide (HCTZ) based on its longer half-life and historical efficacy data. However, recent high-powered pragmatic trials and large-scale observational cohorts challenge this preference. We aimed to synthesise contemporary evidence comparing the...
L. Choonara, M. Vally
· SA Heart · 0 citations