Lewy body (LB) diseases are an umbrella term encompassing a range of neurodegenerative conditions all characterized by the hallmark of intra-neuronal -synuclein associated with the development of motor and cognitive dysfunction. In this study, we have conducted a large meta-analysis of DNA methylation across multiple c...
Joshua Harvey, J. Imm, Morteza Kouhsar et al.· medRxiv· 6 citations
Here, we conduct a large meta-analysis of DNA methylation across multiple cortical brain regions, in relation to increasing burden of Lewy body pathology. Utilizing a dataset of 1205 samples (832 unique donors), we identify 24 false discovery rate significant differentially methylated loci associated with Lewy body pat...
Joshua Harvey, J. Imm, Morteza Kouhsar et al.· Nature Communications· 0 citations
Dementia with Lewy Bodies (DLB) is the most common neurodegenerative dementia after Alzheimer’s disease (AD), but it remains challenging to diagnose due to overlapping symptoms and mixed pathologies. This pilot study tested whether DLB has different metabolic blood proteomic profiles compared to AD and controls. Serum...
Ariana Pritha, L. Chouliaras, P. Swann et al.· International Journal of Mol...· 0 citations
Examination of blood-based T-cell profiles across a range of neurodegenerative dementias provides evidence that T-cell dysregulation is not unified in patients with neurodegenerative diseases and observes different involvement across different dementia types establishing adaptive immunity as a key contributor to diseas...
Frederika Malichova, P. Swann, S. Kigar et al.· Alzheimer's Research & Thera...· 0 citations
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