Discovery of Natural Alkaloid Inhibitors of NLRP3 Inflammasome: A Computational Approach Leveraging Brazilian Biodiversity
The NLRP3 inflammasome (NLR family pyrin domain-containing 3) plays a central role in the pathogenesis of several chronic inflammatory diseases, including rheumatoid arthritis, type 2 diabetes mellitus, and Alzheimer disease. However, currently available inhibitors, such as MCC950, present important limitations related...