Author

L. D. de Witte

2 papers indexed here

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Open access Oct 2026

Parkinson’s disease genetic risk converges on Lewy body pathology-associated microglial states

Parkinson's disease (PD) and related -synucleinopathies are defined by the spread of Lewy body (LB) pathology across vulnerable brain regions, yet how substantia nigra (SN) myeloid cells respond remains unresolved. Using SOX10-based oligodendrocyte depletion and CD11b-based myeloid enrichment, we profiled 169,799 brain...

Raphael Kübler, Daniele Mattei, J. O. Narcís et al. · medRxiv · 0 citations

Open access Aug 2026

Development and validation of a long-term co-maturation protocol for human stem cell-derived microglia and neuronal networks

A co-maturation protocol that robustly generates glutamatergic neuronal networks containing hiPSC-derived microglia and induced the typical ramified microglia morphology and characteristic microglia-neuron interactions is presented.

A. Mordelt, I. Schuurmans, Nicky Scheefhals et al. · Stem Cell Reports · 0 citations