L. Demurtas

Isocitrate dehydrogenase (IDH) as target for anticancer therapy in brain and gastrointestinal cancers

Isocitrate dehydrogenase (IDH) enzyme system plays a central role in cellular metabolism, growth, and differentiation, and its mutations are associated with alterations of the cell cycle and production of oncometabolites, promoting tumor development. In this narrative review, we provide an overview of the current evide...