Author

L. Di Croce

3 papers indexed here

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Open access Sep 2026

Cell-cycle control of chromatin creates a therapeutic window for epigenetic therapy in tumors

The relationship between cell cycle length and differentiation competence has been studied in developmental biology, particularly in embryonic stem cells, which show a very short G1 phase required to maintain pluripotency. How and whether this principle operates in cancer— where the cell cycle is deregulated and G1 is...

K. Hayatigolkhatmi, R. Valzelli, E. Ceccacci et al. · bioRxiv · 0 citations

Open access Oct 2026

H3K27M cooperates with ASCL1 to maintain progenitor states and drive gliomagenesis

Histone 3 lysine 27-to-methionine substitutions (H3K27M) drive aggressive diffuse midline gliomas by blocking differentiation of radial glial progenitor cells committed to oligodendrogenesis. We establish prolonged differentiation as a powerful tool to uncover regulators of glioma cell states and demonstrate that t...

Alan L. Jiao, Abolfazl Maghrouni, A. Gutiérrez et al. · Nature Communications · 0 citations

Open access Sep 2026

TANGO6 coordinates transcription and translation through nucleocytoplasmic partitioning

Coordinated RNA and protein synthesis is fundamental to cell function and survival. Here, we show that TANGO6, a nucleocytoplasmic RNA binding protein, is an integral component of the proteostasis control axis, regulating both transcription and translation. In the nucleus, TANGO6 is recruited to gene promoters alongsid...

Gonzalo Bigliani, C. Ballaré, José Wojnacki et al. · Science Advances · 0 citations