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Author

L. Eriksson

2 papers indexed here

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Open access Aug 2026

Targeting Insulin Signaling and TRAF2/JNK Pathway: A Comprehensive In Silico Study of Uncaria tomentosa Compounds

Type 2 diabetes (T2D) is a metabolic syndrome frequently associated with obesity and endoplasmic reticulum stress-mediated inflammation, which can trigger the unfolded protein response (UPR), impair insulin signaling, and promote apoptosis. To identify potential natural therapeutic candidates, this study investigated t...

Bruna Freitas Marchi, Shraddha Parate, V. Jha et al. · 0 citations
Open access Jul 2026

COMPASS: A Computational Pipeline to Identify Linkers Predicting Ubiquitinable PROTAC‐Induced Ternary Complexes

PROteolysis TArgeting Chimeras (PROTACs) are bifunctional molecules designed to induce targeted protein degradation by forming a transient ternary complex between an E3 ubiquitin ligase and a protein of interest (POI), leading to the E3‐mediated ubiquitination of the POI and its subsequent proteasomal degradation. Alth...

Sébastien Sueron, S. J. Mahdizadeh, Eric Chevet et al. · 0 citations

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