Modeling of ex vivo immune response reveals a central role for CD8+CD25+ cells in Adult T-cell Leukemia survival: a long-term prospective cohort study
Adult T-cell leukemia (ATL) is a rare but aggressive CD4+CD25+ leukemia triggered by HTLV-1 infection. We quantified ex vivo levels of CD4+ and CD8+ (sub)populations and their antiproliferative, pro-apoptotic, antiviral and immunomodulatory interplay in short-term culture of primary cells from ATL patients, in a long-t...