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L. Fisch

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Open access Aug 2026

The timeline of brain aging in major depression: A prospective study from before first-onset to established illness

Major depressive disorder (MDD) has been associated with accelerated structural brain aging, yet whether this reflects a pre-existing neurobiological vulnerability, a dynamic acute state effect, or an accumulating biological residual remains unresolved. Across two longitudinal cohorts (N=3220), including a unique sampl...

M. Konowski, A. Kraus, J. Goltermann et al. · 0 citations
Open access Aug 2026

From gut to brain: data-driven evidence suggests causal contribution of gut-microbiota to major depressive disorder in humans

This study provides the first data-driven evidence for a potential causal role of gut microbiota in the pathophysiology of depression in humans, and employs state-of-the-art causal inference tools within Judea Pearl's framework.

L. Fehse, A. H. Ribeiro, N. Winter et al. · 0 citations

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