Objective Toll-like receptor (TLR) activation by cartilage-derived damage-associated molecular patterns contributes to osteoarthritis (OA) pathogenesis, but the role of synovial fibroblasts in this process remains incompletely understood. We investigated the TLR responsiveness of human OA synovial fibroblasts and deter...
Yu-Jie Dai, Ao Gong, N. Durán-Hernández et al.· bioRxiv· 0 citations
This work shows that MDA5 binds aberrant host RNA induced during viral infection, and proposes that MDA5 surveys RNA processing fidelity and can detect infections by sensing perturbations of post-transcriptional events such as splicing.
Natália G. Sampaio, Tanja Davis, L. Gearing et al.· Nature Immunology· 1 citation
A robust, reproducible, efficient serum-free and feeder-free protocol for generating functional iMacs and characterizing their innate immune properties, providing a versatile model for investigating innate immunity, host-pathogen interactions, and interferon signaling.
Hani Hosseini Far, Le Ying, L. Gearing et al.· Journal of Innate Immunity· 0 citations
Bone metastases showed marked suppression of tumor-intrinsic type I interferon (IFN-I) signaling and loss of antigen presentation, features that were strongly associated with reduced bone metastasis-free survival and could inform precision therapeutic strategies for PCa.
Katie L. Owen, L. Gearing, B. Niranjan et al.· Cancer Research· 0 citations
We use cookies to run the site and, with your consent, for analytics and to show ads.
See our Cookie Policy.
