Author

L. Gomez

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Open access Aug 2026

Methylation clocks fail to generalize across genetically admixed individuals

Epigenetic aging clocks based on DNA methylation patterns across the genome have emerged as a potential biomarker for risk of age-related diseases, like Alzheimer’s disease (AD), and environmental and social stressors. However, methylation clocks have not been comprehensively validated in genetically diverse individual...

Sebastián Cruz-González, Ogechukwu Okpala, Esther Gu et al. · eLife · 0 citations

Open access Sep 2026

Single-cell transcriptomic atlas of Alzheimer's disease middle temporal gyrus reveals region, cell type, and sex specificity of gene expression with novel genetic risk for MERTK in female

A single cell atlas of middle temporal gyrus revealed a unique cellular-level view of sex-specific transcriptional changes in AD, illuminating GWAS identification of sex-specific AD genes.

Le Zhang, Tian-Yu Liu, Chuan He et al. · Journal of Alzheimer's Disea... · 1 citation