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Author

L. Gong

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Aug 2026

Calcified pituitary adenomas: First comprehensive characterization of a distinct clinical entity driven by GNAQ-mediated calcium-mitochondrial axis.

Calcification in pituitary adenomas is a rare phenomenon, observed in only 0.2% to 8% of imaging studies and 5.4% to 25% of histopathological analyses, which complicates diagnosis and surgical intervention, yet its molecular underpinnings remain largely unknown. In this study, we retrospectively analyzed 115 patients w...

Changjun Rao, L. Gong, Jingyuan Jia et al. · 0 citations
Open access Jul 2026

Dual-Target Inhibition of CDK5 and PBK in Pituitary Neuroendocrine Tumors: Mechanisms and Therapeutic Potential

The CDK5-PBK mutual phosphorylation axis serves as a key driver of invasiveness in PitNETs and proguanil hydrochloride represents a promising candidate dual-target therapeutic agent capable of disrupting this pathway to suppress tumor growth.

Jinghao Jin, Zhaoyi Yi, Hong-Yun Wang et al. · 0 citations

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