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L. Gragnani

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Open access Aug 2026

Kdm2a histone demethylase ablation restores anti-tumor immunogenicity in liver cancer.

BACKGROUND Liver cancer remains a major global challenge, with limited benefit from immune checkpoint inhibitors due to strong immune evasion. Emerging evidence indicates that chromatin modifiers shape tumor immunogenicity, but their roles in liver cancer immunity are not fully understood. METHODS We investigated the...

L. Gragnani, M. Lulli, Patrizio Caini et al. · 0 citations
Review Open access 2026

Cancer-Associated Fibroblasts-Orchestrated Immune Remodeling as a Key Driver in Liver Cancer

: Hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (iCCA) develop within a highly immunosuppressive tumor microenvironment (TME) characterized by chronic inflammation, extensive stromal remodeling, and impaired antitumor immunity. Among stromal components, cancer-associated fibroblasts (CAFs) have eme...

N. Porro, Silvia Marri, F. Salani et al. · 0 citations

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