L. Grinberg

Generalizing Amyloid β Pathology from Postmortem Human Brains with Vision Foundation Models for Lesion Quantification

Tau‐associated neuronal loss in the intermediate nucleus of the human hypothalamus, a putative VLPO analog, in progressive supranuclear palsy and Alzheimer's disease

Sleep phenotypes differ in progressive supranuclear palsy (PSP) and Alzheimer's disease (AD). The human intermediate nucleus (IntN), a putative ventrolateral preoptic analog, promotes non‐rapid eye movement (NREM) sleep, but its disease‐specific vulnerability is unclear.

Lewy Body Disease Across Aging: Clinical and Neuropathological Correlates in a Population Brain Bank.

BACKGROUND Lewy body disease (LBD) is defined by neuronal α-synuclein pathology, but how Braak-staged LBD relates to mixed neuropathology and clinical manifestations within a single population-based cohort remains incompletely characterized. This is especially relevant in cohorts enriched for younger individuals, which...

Subcortical correlates of sleep in aging and Alzheimer’s disease: an in vivo study

Abstract Sleep disturbances are frequently observed in patients with neurodegenerative diseases, but in vivo evidence linking subcortical sleep–wake structures to sleep phenotypes is limited. We aim to examine associations between MRI-derived measures of subcortical sleep–wake regulating regions and polysomnographic sl...

Atypical Alzheimer disease: a multi-axis framework toward defining heterogeneity.

A practical multi-axis framework comprising clinical phenotype, AD biological context (AD pathology plus co-pathologies and molecular modifiers), network topography (regional patterns) and tempo (rate of clinical and biomarker progression) is proposed to reduce diagnostic mismatches, make cohorts more comparable and su...

Transplantation of human iPSC-derived microglia ameliorates neuropathology and circuit dysfunction in progranulin-deficient mice.

It is found that engraftment of wild-type, but not Grn-deficient, human microglia restore brain-wide progranulin levels, normalize microglial transcriptional states, and ameliorate pathological, functional, and behavioral phenotypes associated with progranulin loss.

Sex and the clock: Exploring sex differences in chronotype and circadian behavior among healthy older adults

Preliminary evidence of the relationship between subjective sleep preferences and objective circadian data in cognitively healthy older adults with notable sex differences in these relationships is provided.

Targeted proteomics of postmortem human brain reveals neurobiologic heterogeneity in Alzheimer’s disease using NULISA technology

Proteomic differences in synapse integrity, tau post-translational modification, and ubiquitination associated with age at symptomatic onset and corticolimbic distribution of tangle pathology are observed.