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Author

L. Guillot

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2 papers indexed here

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Open access Jul 2026

SppR in Streptococcus mutans coordinates stress tolerance response and BrpA expression

SppR is a transcriptional repressor of fructanase FruA and fructose-1-phosphatase SppA. In this study, a frameshift sppR mutant was constructed and analyzed using in vitro biofilm models and stress challenge assays for its role in S. mutans’ stress tolerance response and biofilm formation. In addition, luciferase repor...

Zezhang T. Wen, Bo Yang, L. Guillot et al. · 0 citations
Open access Jul 2026

An XRE-type regulator in Streptococcus mutans plays an important role in brpA expression and oxidative stress tolerance response

ABSTRACT This study used a functional genomics approach to explore the role of a xenobiotic response element (XRE)-type regulator (SMU.405c) in Streptococcus mutans physiology, including the expression of biofilm regulatory protein BrpA. Results showed that deletional mutation of xre significantly reduced the ability o...

Zezhang T. Wen, K. Ellepola, L. Guillot et al. · 1 citation

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