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Sponsored Design Multi-Agent AI Systems Using MCP and A2A: Engineer your own Pyt Design Multi-Agent AI Systems Using MCP and A2A: Engineer your own Pyt

Author

L. Heitman

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Open access Sep 2026

From Phenotypic Screening to Target and Compound Prioritization for Autosomal Dominant Polycystic Kidney Disease.

Autosomal Dominant Polycystic Kidney Disease (ADPKD) is a progressive kidney disorder with limited therapeutic options, highlighting an urgent need for safer, long-term treatments. This study presents a multi-step computational and experimental approach to identify and assess target-based hypotheses for mechanisms unde...

D. Araripe, Margarita Iljin, H. Bange et al. · 0 citations
Oct 2026

Design and Development of New Dual Target Agents, Cannabinoid Subtype 2 Receptor (CB2R) Agonists, and Fatty Acid Amide Hydrolase (FAAH) Inhibitors against Neurodegeneration

As dual modulators of Cannabinoid subtype 2 receptor (CB2R) and fatty acid amide hydrolase (FAAH)an arising therapeutic strategy against diseases based on neuroinflammationwe developed a new series of N-adamantyl-benzamides bearing an anthranilic or salicylic scaffold. Derivatives 18, 22, and 25 emerged as an inter...

Giovanni Graziano, Francesco Mastropasqua, A. Fanizzi et al. · 0 citations
Open access Aug 2026

Enterochromaffin cells as a cellular integration hub for cooperative microbial signaling to modulate gut serotonin and motility

The intestinal epithelium is exposed to diverse combinations of microbiota-derived compounds; however, the mechanisms by which the host integrates these signals remain poorly defined. Studying two highly abundant microbial metabolites, we identified the purine metabolite hypoxanthine as an effector metabolite that dire...

Yang Xiao, T. Louwies, R. Mars et al. · 0 citations
Open access Jul 2026

Automated Parallel Synthesis Accelerates Virtual Screening Hit Discovery

ComBINAUT is an automated parallel synthesis platform that generates diverse chemical scaffolds to accelerate hit validation and refinement, enabling the efficient exploration of chemical space and the rapid discovery of novel ligands.

Sean M. McKenna, M. Šícho, Cas van der Horst et al. · 0 citations

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