Author

L. Joosten

2 papers indexed here

We haven’t gathered this author’s papers yet. Follow them and we’ll fetch their work.

Not the right person? Other researchers publish under this name.

Aug 2026

ACC1 inhibition enhances BCG-induced trained immunity by reprogramming Acetyl-CoA metabolism.

Trained immunity enhances long-term innate immune responsiveness through metabolic and epigenetic rewiring. Using BCG as a model, we demonstrate that inhibition of acetyl-CoA carboxylase 1 (ACC1) enhances BCG-induced trained immunity by increasing intracellular acetyl-CoA (ACoA) availability. This shift redirects ACoA...

Ilayda Baydemir, Fabian Nikolka, Ö. Bulut et al. · Molecular Therapy · 0 citations

Review Open access Sep 2026

The Interplay between Innate Immune Memory and Adaptive Immunity: Emerging Mechanisms in Alloimmunity.

Innate immune memory is increasingly recognized as a regulator of immune responses in solid organ transplantation. Following an initial stimulus, innate immune cells and their progenitors can undergo epigenetic and metabolic reprogramming, resulting in enhanced or suppressed pro-inflammatory responses upon subsequent e...

Maaike M. E. Jacobs, Lisanne C. de Jong, N. Rother et al. · American Journal of Transpla... · 0 citations