Open access
Aug 2026
Erosion of regenerative regulation: age-associated shifts in the skeletal muscle fiber epigenome and transcriptome
Together, these findings identify an age-associated regulatory shift, largely invisible in matched transcriptomic data, characterized by closing chromatin which reduces accessibility to hormone receptor binding sites and enhancer regions in the muscle fiber epigenome.
Keagan G. Moo, Peter Orchard, Arushi Varshney et al.
· bioRxiv · 0 citations