Author

L. Klei

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Open access Sep 2026

Proteomic profiling across early postnatal development of midbrain dopamine axons innervating the dorsal striatum

Precise wiring and tuning of dopamine axons in the brain is crucial for normal development of basal ganglia circuits. This process takes place both pre and postnatally, with early postnatal windows reflecting important periods of terminal maturation. Protein expression and precise localization are vital to this process...

Meghan Masotti, L. Klei, Akayla Lewin et al. · bioRxiv · 0 citations

Open access Sep 2026

Autism genes converge on three functional programs organized by neuronal subclass, developmental timing, and cortical patterning

Together, these findings anchor ASD genetic vulnerability to specific neurodevelopmental lineages, epochs, and molecular substrates, and delineate the features that distinguish ASD from comorbidities with broader developmental impacts.

Rachel L. Smith, Yun-Dan Liao, L. Klei et al. · bioRxiv · 0 citations

Open access Aug 2026

Rare variation illuminates the distinct and pleiotropic genetic architecture of autism across neuropsychiatric traits

This study finds that rare variants across hundreds of genes contribute to autism with variable phenotypic outcomes, and clusters them based on association evidence from large-scale studies of developmental disorders, schizophrenia, bipolar disorder, and epilepsy.

F. Satterstrom, C. Auwerx, J.-M. Fu et al. · medRxiv · 1 citation