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Author

L. Klein

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Sep 2026

Abstract A039: Epigenetic regulation of cellular heterogeneity and the tumor-immune landscape in pancreatic cancer

Cellular heterogeneity in pancreatic ductal adenocarcinoma (PDAC) poses significant challenges for disease prognosis and limits the effectiveness of therapeutic strategies implemented in recent multicenter subtype-based clinical trials worldwide. A hallmark of PDAC is extensive intratumoral heterogeneity, which is la...

Xue-Yan Wu, L. Klein, M. Tu et al. · 0 citations
Open access Aug 2026

Targeting addiction to HMGB2-driven transcriptional programs in pancreatic cancer.

A small molecule inhibitor is repurposed to interfere with its binding to DNA, restrict chromatin accessibility at promoters, and constrain tumor growth both in vitro and in vivo to show how increased HMGB2 availability represents a transcriptional addiction that fuels cell-cycle progression and growth.

Adi Danieli-Mackay, Ioanna Papadionysiou, Markos Tsitsianopoulos et al. · 0 citations

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