Author

L. L. Yung

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Sep 2026

A Signal Turn-On DNA Proximity Assay That Correlates with SARS-CoV-2 Blocking Antibody Levels

Surrogate in vitro assays have enabled the scalable testing of neutralizing antibodies to SARS-CoV-2 as a toolbox to manage the post-COVID-19 situation and future outbreaks. However, most surrogate assays use a competitive format to mimic the blocking event between the receptor binding domain (RBD) and the human angi...

Shan-Ang Yan, L. L. Yung · Analytical Chemistry · 0 citations

Jul 2026

Sequence Engineering of Guide DNA for Precise RNA Targeting by Cas12a.

Cas12a is highly accommodative toward noncanonical activation pathways to the extent of flipping its identity to be a DNA-guided RNA-targeting effector. A sequence engineering approach was used to systematically identify desirable guide DNA (gDNA) sequence motifs to achieve comparable RNA targeting efficiency as the ca...

Shan-Ang Yan, L. L. Yung · ACS Nano · 0 citations