Author

L. Lareau

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Open access Aug 2026

Prefoldin function links meiotic chromosome segregation with cellular remodeling and reveals tubulin sensitivity of the meiotic spindle

This work identifies Gim3, a subunit of the ubiquitously expressed and conserved prefoldin complex, as a critical regulator of meiotic but not mitotic chromosome segregation in budding yeast and reveals an exciting and previously unrecognized link between chromosome segregation and meiotic cellular remodeling.

Naohiro Kuwayama, Benjamin S. Styler, Bojana Stekovic et al. · Science Advances · 0 citations

Open access Aug 2026

Reprogramming Cas9 PAM Recognition for Allele-Specific Editing

A yeast selection platform is developed to engineer Cas9 with re-specified activity across multiple additional non-canonical PAMs in yeast, further demonstrating its utility as a general and programmable framework for expanding the therapeutic reach of precision genome editing.

Julia Tartaglia, Vivian Nguyen, John James Desmarais et al. · bioRxiv · 0 citations