Open access
Sep 2026
Mutations in the macrodomain 1 of nsp3 attenuate PEDV virulence in vivo without impairing in vitro replication
This work provides the first in vitro and in vivo evidence that the conserved N462 residue in the PEDV Mac1 domain is critical for both ADP-ribose binding and hydrolysis, induces IFN production, and contributes to virulence.
Ming-De Liu, Men Thi Hoai Duong, Thamonpan Laocharoensuk et al.
· Journal of Virology · 0 citations