A systematic consolidation of current evidence supporting the involvement of CNNM2 in SCZ pathogenesis provides a direction for further investigation of the pathological mechanisms underlying this disease, and for identification of novel targets for clinical intervention.
Yang Jin, Li-Ge Zhang, Xiaoyi Yao et al.· Neuroscience· 0 citations
This work delivers the most thorough delineation of BD-associated CNVs in Han Chinese to date, underscoring the imperative for ancestry-inclusive research to comprehensively unravel psychiatric genomics and unveiling fresh mechanistic perspectives on BD etiology.
Yong Wu, Xiangyu Li, Yao-Yao Sun et al.· Molecular Psychiatry· 0 citations
Findings indicate that anatomically grounded node-level multimodal fusion can improve classification performance while preserving neurobiological interpretability, thereby providing a principled framework for multimodal schizophrenia classification and biomarker discovery.
Jing-Jing Gao, J. Wu, Mao-Min Qian et al.· Medical Image Anal.· 0 citations
Schizophrenia (SCZ) involves immune dysregulation and synaptic deficits, yet the molecular link between peripheral inflammation and central synaptic pathology remains unclear. We integrated blood transcriptomes from four SCZ cohorts (478 samples: 245 patients, 233 controls) and validated findings in single-cell brain d...
