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L. M. Occulate

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Review Open access 2026

Psychiatric Emergency in Depression, Systemic Inflammation, Biochemical Changes, Biomarkers of Severity, and Therapeutic Response

Depression is a major cause of disability and can present in severe forms associated with suicidal behavior, treatment resistance, and the need for psychiatric emergency care. This systematic review aimed to analyze recent evidence on systemic inflammation, biochemical abnormalities, and biomarkers related to severity,...

Fernanda Lourenço Faggioni, Marcos A. Couto, Vinicius Maltha Do Nascimento et al. · 0 citations
Review Open access Aug 2026

Menopause and Skin Aging in Primary Health Care: The Impact of Hormone Therapy on Skin Health and the Role of the Family and Community Doctor

Introduction: Menopause is a physiological process characterized by the permanent cessation of ovarian function and a reduction in estrogen production, triggering structural and functional changes that accelerate skin aging. Among the main manifestations are reduced dermal thickness, loss of collagen, decreased elastic...

R. R. Cristofolini, Ana Luiza Zampar Quintana Gomes, Marcela Ferreira Prado et al. · 0 citations
Review Open access 2026

Therapeutic Use of Ketamine and Esketamine in Treatment-Resistant Depression: Clinical Evidence and Future Prospects

It is concluded that ketamine and esketamine represent important therapeutic advances in the treatment of treatment-resistant depression, particularly due to the rapid clinical response and the potential to reduce the risk of suicide.

Marcos A. Couto, Flávia Eduarda Pereira Januário, Gabriela de Luna Costa Pinheiro et al. · 0 citations

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