Author

L. Marraffini

2 papers indexed here

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Open access Sep 2026

MtvS1 and MtvS2 Interact with RNA polymerase to regulate the Francisella type V-A CRISPR-Cas system

Bacteria and archaea often harbor multiple CRISPR-Cas loci to defend against mobile genetic elements. Little is known, however, about whether and how different CRISPR-Cas systems are differentially regulated, in many instances due to the impossibility of studying CRISPR immunity in native hosts. Here we investigated th...

M. Brodmann, Christian F. Baca, Joshua Chandanani et al. · Nature Communications · 0 citations

Open access Aug 2026

A lipid fenestration-gated membrane depolarization mechanism expands the repertoire of CRISPR-mediated anti-phage defense strategies

This work characterize Chp1, a membrane-embedded CARF effector that assembles as a tetrameric pore harboring autoinhibitory lipid fenestrations that occlude the pore in the inactive state, and uncover a lipid-gated mechanism that expands the repertoire of CRISPR-mediated defense strategies.

P. Majumder, Heloise Carion, G. Stella et al. · bioRxiv · 0 citations