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Author

L. McGregor

2 papers indexed here

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Open access Aug 2026

Covalent Stabilizers of the Interaction Between 14-3-3σ and Estrogen Receptor‑α.

Selective stabilization of complexes formed by the hub protein 14-3-3 represents an emerging mechanism for the modulation of therapeutically relevant targets. In this letter, we describe a hit-finding campaign designed to identify small molecule stabilizers of the interaction between 14-3-3σ and the estrogen receptor a...

R. Jain, Mark Knapp, S. Kochanek et al. · 1 citation
Open access Jul 2025

Expanding the repertoire of chemically induced covalent neoantigens

The ubiquitin-proteasome system generates peptide fragments that are displayed on MHC-I molecules. Recent studies revealed that covalent small molecules can hijack this process, leading to the presentation of hapten-modified peptide fragments, or covalent neoantigens. Here, we report a chemical proteomics platform to s...

Chen Zhou, Wei Huang, Xiaokang Jin et al. · 0 citations

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