Author

L. Melstrom

3 papers indexed here

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Sep 2026

Abstract B035: Integrative multi-omics and microbiome profiling reveals molecular and microbial heterogeneity in a diverse cohort of pancreatic ductal adenocarcinoma

Pancreatic ductal adenocarcinoma (PDAC) remains one of the most lethal malignancies, characterized by extensive molecular heterogeneity and persistent disparities in clinical outcomes. Despite recent advances in genomic profiling, the molecular and microbial factors underlying disease heterogeneity across genetic...

F. Carranza, B. Waldrup, S. Manjarrez et al. · Cancer Research · 0 citations

Sep 2026

Abstract A067: Precision medicine-oriented analysis of RTK-RAS signaling in gemcitabine-treated pancreatic cancer using conversational artificial intelligence

Although KRAS mutations represent the hallmark genomic alteration in pancreatic ductal adenocarcinoma (PDAC), the broader receptor tyrosine kinase RTK-RAS signaling landscapes underlying differential responses to gemcitabine remain poorly defined. We performed an integrative clinical-genomic analysis of 15...

C. Cosme, B. Waldrup, F. Carranza et al. · Cancer Research · 0 citations

Sep 2026

Abstract A066: Toward early detection of pancreatic cancer: Somatic genomic profiling of early- and late-onset PDAC in a diverse cohort

The incidence of early-onset pancreatic ductal adenocarcinoma (EO-PDAC) is increasing, yet its molecular characteristics remain poorly defined. Improved understanding of genomic alterations associated with EO-PDAC may facilitate the discovery of biomarkers for earlier detection and precision oncology. We aimed to...

B. Waldrup, F. Carranza, S. Manjarrez et al. · Cancer Research · 0 citations