Author

L. Muhl

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Open access Aug 2026

A reference protein atlas of the adult mouse brain vasculature

This work used isolated brain vascular fragments to study the blood–brain barrier and applied a combination of deep bulk proteomic analysis, a proteomic ruler approach, and scRNA-seq, assuming a high within-gene correlation between mRNA and protein.

Li-Qun He, Henrik J. Johansson, E. Vázquez-Liébanas et al. · Proceedings of the National... · 0 citations

Open access Jul 2026

Single-cell analysis of the progeria arterial wall reveals progerin-induced progressive, cell type-specific dysfunction and somatic mutation accumulation

It is shown that progerin leads to somatic mutation accumulation particularly in VSMCs, highlighting the need for early, cell-type-specific therapeutic intervention in HGPS to prevent permanent vascular tissue damage.

Lara G. Merino, Gwladys Revêchon, Santhilal Subhash et al. · Genome Medicine · 1 citation