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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

Author

L. Neitzel

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Open access Aug 2026

Novel Wnt potentiators induce iPSC-derived cardiomyocyte proliferation and increase embryonic zebrafish heart size.

Canonical Wnt/β-catenin pathway activation can promote cardiomyocyte (CM) cell cycle activity, but translation is limited by off-target and functional liabilities associated with global pathway activation. We identified two small molecules, LRN9 and DF6, which potentiate Wnt/β-catenin signaling through a non-GSK3β mech...

Daniela T Asenjo, Lynn A. C. Devilée, Aaron H. Wasserman et al. · 0 citations
Open access Sep 2026

Ogremorphin induces ferroptosis in primary human glioblastoma neurospheres.

Glioblastoma multiforme (GBM) is the most common and lethal primary brain tumor in adults, with a median survival of only 15 months. While current treatment strategies combine surgery, radiation, and chemotherapy, the majority of cases recur with acquired resistance. Despite considerable heterogeneity within GBM tumors...

Aaron H. Wasserman, Bhavya Tikaria, H. Basrai et al. · 0 citations
Jul 2026

Abstract A023: Inhibition of GPR68 induces ferroptosis in diffuse intrinsic pontine gliomas

Investigation of OGM’s efficacy in inducing ferroptosis in DIPG cells suggested that GPR68 inhibition is an attractive therapeutic target for DIPG, and GPR68 inhibition mirrors the effects observed in GBM, inducing ATF4-dependent ferroptotic cell death.

L. Neitzel, Charles C. Hong · 0 citations

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