Author

L. Neubert

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Open access Aug 2026

Single-cell and spatial transcriptomics resolve airway obliteration in bronchiolitis obliterans syndrome

Background Chronic lung allograft dysfunction (CLAD) is the leading cause of death beyond the first year after lung transplantation, and its most frequent phenotype is bronchiolitis obliterans syndrome (BOS), a fibrotic small-airway disease. Mechanistic work has focused on the immune compartment, yet intensified immuno...

Jannik Ruwisch, Hande Yilmaz, Leonard Christian et al. · bioRxiv · 0 citations

Open access Sep 2026

Multi-modal analysis of vascular remodelling in human obliterative bronchiolitis after lung transplantation.

Chronic lung allograft dysfunction (CLAD) is the leading cause of late morbidity and mortality after lung transplantation. Bronchiolitis obliterans syndrome (BOS), a major CLAD phenotype, is characterized by obliterative bronchiolitis (OB). While microvascular perturbations are described in BOS, their cellular and mole...

Axelle Coppens, Rahel Bodenmann, Janik Riese et al. · American Journal of Transpla... · 0 citations

Open access Jul 2026

Aberrant and Ectopic Cell Populations in Restrictive Allograft Syndrome after Lung Transplantation.

Considering the multifaceted differences of RAS and idiopathic pulmonary fibrosis, a surprising general principle of an entity-spanning composition of the fibrotic niche by aberrant basaloid cells localized at the fibrotic edge, ectopic COL15A1+ pVECs and CTHRC1+ fibrotic fibroblasts is revealed.

L. Leiber, Leonard Christian, L. Neubert et al. · European Respiratory Journal · 0 citations