L. Olivares-Quiroz

Short And Long-Range Effects Of Single-Point Mutations In Sars-Cov2 Main Protease M Pro Using Residue Network Representation

We present a graph-theoretic framework for assessing the connectivity and structural impact of single-point mutations in biological enzymes. The method maps the threedimensional crystallographic structure of a given enzyme into a C α -Protein Residue Network (PRN) where nodes n k represent central C α carbons i...