L. Otterbein

The DAMP Awakens: The Role of Heme and Heme Oxygenase-1 in Organ Transplantation

Ischemia-reperfusion injury (IRI) determines early and delayed graft function and long-term allograft survival in solid organ transplantation and is one determinant of outcome that remains modifiable in the operating room. Cell-free heme, a Danger-Associated Molecular Pattern (DAMP), is liberated from hemoproteins as a...