Author

L. Pagan

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Open access Oct 2026

High-Intensity Interval Training Improves Functional Capacity and Peripheral Skeletal Muscle Energy Metabolism in Infarcted Rats

Introduction: High-intensity interval training (HIIT) has been recommended in post-myocardial infarction (MI) cardiac rehabilitation; however, its effects on MI-induced cardiac remodeling and skeletal muscle remain unclear. This study evaluated the effects of HIIT on functional capacity, cardiac remodeling, and the sol...

T. H. Pontes, G. Brandão, E. Rodrigues et al. · Antioxidants · 0 citations

Open access Oct 2026

Influence of dapagliflozin on cardiac remodeling in aortic stenosis rats: functional assessment and inflammatory and autophagic pathways evaluation

Sodium-glucose co-transporter 2 (SGLT2) inhibitors have beneficial effects in the treatment of heart failure with both preserved and reduced ejection fraction. However, their influence in patients with aortic stenosis-induced heart failure has not been established. In this study, we investigated the effects of th...

É. A. Rodrigues, G. Ohara, P. K. Becaro et al. · European Heart Journal · 0 citations

Open access Oct 2026

Effects of SGLT2 inhibition on cardiac remodeling and heart failure development in aortic stenosis rats

Aortic stenosis (AS) is increasingly prevalent in ageing populations, yet no pharmacological therapy has been shown to modify its progression to heart failure (HF). Sodium glucose cotransporter 2 (SGLT2) inhibitors improve outcomes in HF, but their effects in pressure overload-induced cardiac remodeling remain unclear....

L. Pagan, M. J. Gomes, M. Gatto et al. · Molecular Biomedicine · 0 citations