Brain connectivity disruption is a hallmark of neurodegenerative disorders, including Alzheimer's disease (AD), yet how network breakdown gives rise to cognitive deficits remains unclear. Here, we review the evidence bearing on three interconnected processes that have been proposed to link molecular pathology to cognit...
L. Pini, Catalina Campuzano, Lu Zhang et al.· Neuroscience and Biobehavior...· 0 citations
Abstract Recent studies show that serum glial fibrillary acidic protein (GFAP) is highest in healthy infancy and early childhood and then declines steadily with age, while plasma tau protein phosphorylated at position 217 is strikingly elevated in healthy newborns and can exceed values observed in Alzheimer’s disease (...
L. Pini, M. Margoni, Massimo Filippi et al.· Brain Communications· 0 citations
Understanding how intrinsic brain dynamics are organized is critical for explaining human cognition and sensory processing. Theoretical frameworks propose a hierarchical architecture in which some neural systems act as orchestrators, broadcasting information across the brain, whereas others serve as integrators, transf...
L. Pini, Ranieri Dugo, Paolo Pigato et al.· bioRxiv· 0 citations
Interventions for Alzheimer's disease (AD) have repeatedly been advanced from epidemiological associations, biological hypotheses and preclinical findings, yet many have failed in randomized trials and some have produced signals of clinical worsening. We examine illustrative successful and unsuccessful programs across...
B. Imbimbo, Nunzio Pomara, L. Pini et al.· Biomedicine & pharmacotherap...· 0 citations
Focal brain lesions are thought to induce sleep-like slow-wave activity in perilesional cortex through altered excitation-inhibition balance and structural disconnection, but whether these dynamics extend to remote yet structurally intact regions remain unclear. Here we combined source-reconstructed high-density EEG (1...
Ilaria Mazzonetto, Miriam Celli, L. Pini et al.· bioRxiv· 0 citations
Brain regions are organized into large-scale networks through dynamic functional connections that support sensorimotor and cognitive processes across the lifespan. Age-related disruptions of these functional systems are associated with cognitive and motor decline and increased risk of neurocognitive disorders. A growin...
F. Gennaro, L. Pini, Maurizio Corbetta et al.· Ageing Research Reviews· 0 citations
A dual‐domain framework is proposed in which tau‐targeted therapies are evaluated using complementary measures of aggregated tau burden and biologically defined soluble tau states, and treatment‐induced increases should be considered favorable only when they accompany aggregate reduction and evidence of a less pathogen...
C. Teunissen, L. Pini, B. Imbimbo· Alzheimer's & Dementia· 0 citations
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