L. Prolo

Adolescent development accelerates responses to input in human neocortical neurons

Through childhood and adolescence, profound changes to the physiology of individual neurons accompany large-scale network changes in the mammalian neocortex. These physiological changes are well understood in rodent models but far less is known in the human neocortex. Here we combine patch-clamp electrophysiology and s...

MRI-based radiomics for prognosis of non-midline, pediatric high-grade gliomas

Epilepsy outcomes following single and repeat epilepsy surgeries in tuberous sclerosis complex.

OBJECTIVE Epilepsy surgery in tuberous sclerosis complex (TSC) is underutilized but associated with improved seizure control and better neurocognitive outcomes. Here we focus on utilization of repeated surgeries to improve seizure control. METHODS We performed a retrospective chart review of 62 pediatric patients wit...

Utility of repeat stereotactic EEG in pediatric patients with tuberous sclerosis

It is suggested that repeat sEEGs may help guide effective treatment in children with multifocal epilepsy, while multifocal networks may necessitate additional sEEG evaluations and subsequent surgeries, favorable seizure outcomes can be achieved.