Open access
Aug 2026
TRIB3 promotes triple-negative breast cancer metastasis by restricting lipophagy through the PI3K/AKT/mTOR signaling pathway.
A previously unrecognized mechanism by which TRIB3 regulates lipophagy to drive TNBC metastasis is uncovered, highlighting TRIB3 as a central mediator of TNBC progression and suggesting novel therapeutic strategies targeting lipophagy for this aggressive breast cancer subtype.
L. Ruan, Jian-Feng Liu, Zirong Jiang
· Cellular Signalling · 0 citations