Author

L. Soraci

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Review Open access Sep 2026

Cardiorenal Syndrome: Pathophysiology, Management, and the Challenge of Therapeutic Inertia

Cardiorenal syndrome describes the clinical consequences of the bidirectional influence that cardiac and renal dysfunction exert on each other—a domain in which single-organ care proves insufficient. A 2024 meta-analysis estimated the pooled prevalence of chronic kidney disease among patients with heart failure at 49%....

G. Gembillo, V. Calabrese, L. Soraci et al. · Medicina · 0 citations

Review Open access Sep 2026

CAR-T Cell Therapy in Nephrology: Evidence Across Immune-Mediated Kidney Diseases and Plasma Cell Dyscrasias, Renal Toxicity, and Patient Monitoring

In many immune-mediated kidney diseases, tissue injury is driven by dysregulated B-cell immunity, with autoantibodies and complement acting as key effectors at the glomerulus. Corticosteroids and conventional immunosuppressants control these diseases only in part, and they do so at the price of cumulative toxicity and...

L. Visconti, L. Soraci, Lorenzo Lo Cicero et al. · Future Pharmacology · 0 citations

Open access Sep 2026

Diagnostic Accuracy and Alignment With Human Reader Responses Across Five Large Language Models on Complex Clinical Case Challenges

Introduction: Large language models (LLMs) match or exceed physician accuracy on benchmark diagnostic tasks. Whether higher accuracy reflects human-like diagnostic behavior, which bears on how safely clinicians can supervise these systems, is rarely assessed. Objectives: To determine whether diagnostic accuracy and al...

R. Bellocco, L. Soraci, Lorenzo Lo Cicero et al. · Epidemiology Biostatistics a... · 0 citations