AMD1 regulates cysteine metabolism and ferroptosis sensitivity in rheumatoid arthritis fibroblast-like synoviocytes.
BACKGROUND Rheumatoid arthritis (RA) is characterized by synovial inflammation and hyperplasia, with fibroblast-like synoviocytes (FLS) playing a key pathogenic role. Cysteine metabolism is central to redox homeostasis and ferroptosis regulation, yet its mechanisms in RA-FLS remain poorly understood. This study investi...