Author

L. V. Van Nynatten

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Review Open access Sep 2026

Heterogeneity of Treatment Effect by Molecular Endotype in Acute Respiratory Distress Syndrome: A Systematic Review.

RATIONALE Despite numerous randomized controlled trials (RCTs) in acute respiratory distress syndrome (ARDS), few have identified effective therapies. One reason may be heterogeneity of treatment effect (HTE), in which distinct subgroups respond differently to the same intervention, potentially reflective of underlying...

L. V. Van Nynatten, Chris McChesney, Mujtaba M. Basharat et al. · Annals of the American Thora... · 0 citations

Review Open access Jul 2026

The molecular ICU: a primer on omics, informatics and the future of precision critical care

This Review proposes pathway-focused biomarkers as clinically translatable signatures that preserve biological mechanisms while enabling practical measurement, and outlines how pathway enrichment, network analysis, and multi-omic integration can identify these programs, and how feature selection can derive parsimonious...

L. V. Van Nynatten, Hira Raheel, J. Basmaji et al. · Critical Care · 2 citations