The impact of intratumor heterogeneity on outcome and resistance to therapy in primary breast cancer: a systematic review
Intratumor heterogeneity (ITH), the coexistence of diverse subclones within a single tumor, may pose a major challenge to effective chemotherapy in breast cancer. This cellular diversity contributes to treatment failure, residual disease, and early relapse by enabling tumor adaptation and therapeutic resistance. Althou...
Aria Dianati, Andre Dekker, A. Wesselius et al.
· Medical Oncology · 0 citations